The main goal of the proposed project is an entirely new telemedicine product - the online prediction system AMPHORA for the remote therapy of patients with heart failure. The system will consist of two major components - the AMPHORA-Cloud application for data acquisition and handling and the AMPHORA-AI application for heart failure progression prediction, based on artificial intelligence methods. These methods will use data from different modalities (patient biophysical data, subjective status, etc.) to generate a prediction model for early diagnosis of disease progression for a wide range of patients. It is expected that the AMPHORA will become MDT's flagship product, significantly strengthening the company's economic position in biotechnological market in Czechia and abroad.