Analytical methods for advanced identification of ventricular dyssynchrony

The basis of the project is to discover methods able to precisely identify properties of very weak electrocardiographic potentials. These potentials are measured with high dynamic acquisition system, its frequency range reaches up to 2 kHz and amplitude resolution is in nV (UHF-ECG). UHF potentials reflect spatial-temporal distribution of electrical myocardial depolarization and ventricular electrical dyssynchrony. Since the UHF potentials in ECG signal represent completely novel measure, there is a lack of methodological background. These are primarily methods for precise QRS position identification, QRS sorting to categories, elimination of stimulation peaks, assessment of information content in different frequency bands, computation of UHF numerical descriptors. Probably the most important research covers interpretation of UHF methods for heart dyssynchrony diagnostics and the relation between electrical and mechanical activation of myocardium.