Equipment
Our facility specializes in highly experimental magnetic resonance imaging and spectroscopy in small laboratory animals for biomedical research, which is reflected by the equipment. The key items are the small-animal high-field MR scanner with a bore diameter and transmit and receive coils allowing measurement of mice, rats, or rabbits, and the certified animal facility, which includes the whole laboratory building. Additional equipment supports animal model preparation, animal welfare compliant with the 3R rules, physiologic monitoring and anesthesia during the measurement, blood-brain barrier opening by MR-compatible focused ultrasound, and computation infrastructure.
• suitable for mice, rats and rabbits
• 30-cm bore; 660 mT/m gradients for mice and rats, 300 mT/m for rabbits
• nuclei 1H, 13C, 19F, 23Na, 31P, 129Xe
• mouse/rat head/body volume/surface/array RF coils ( mononuclear 1H: volume resonator coils (T/R, circularly polarized, inner diameters 154, 86, 60, 40 mm), array coils (R, 2×2 surface mouse brain, 2×2 surface rat brain, volume 8×1 rat head), surface single-loop coils (R, linear, diameters 10, 20, 30 mm)); binuclear saddle coils (TR, linear, inner diameter 40 mm: H/C, H/F, H/Na, H/P, H/Xe), surface single-loop coils (TR, diameter 20 mm: H/C, H/F, H/Na, H/P, H/Xe
• mouse-brain cryoprobe – high sensitivity
• equipment for general anesthesia
• physiology monitoring and stabilization (temperature, ECG, respiration, blood oxygenation)
• MR-compatible model FUS Instruments RK-300 0.5-2 MHz
• ellipsoidal focus volume 15 mm x 1.5 mm
• localized heating
• blood-brain-barrier opening
• specific pathogen free, BSL-1, 1st-category GMO
• 200 mice + 100 rats in separate rooms
• individually ventilated cage systems
• flow-boxes
• hygienic loop
• autoclave
• sterilization chamber
