%0 Journal Article %J Opt. Express %D 2019 %T Label-free CARS microscopy through a multimode fiber endoscope %A Johanna Trägårdh %A Tomáš Pikálek %A Mojmír Šerý %A Tobias Meyer %A Jürgen Popp %A Tomáš Čižmár %K KF %K MF %X

Multimode fibres have recently been employed as high-resolution ultra-thin endoscopes, capable of imaging biological structures deep inside tissue in vivo. Here, we extend this technique to label-free non-linear microscopy with chemical contrast using coherent anti-Stokes Raman scattering (CARS) through a multimode fibre endoscope, which opens up new avenues for instant and in-situ diagnosis of potentially malignant tissue. We use a commercial 125 &\#x00B5;m diameter, 0.29 NA GRIN fibre, and wavefront shaping on an SLM is used to create foci that are scanned behind the fibre facet across the sample. The chemical selectivity is demonstrated by imaging 2 &\#x00B5;m polystyrene and 2.5 &\#x00B5;m PMMA beads with per pixel integration time as low as 1 ms for epi-detection.

%B Opt. Express %V 27 %P 30055–30066 %G eng %U http://www.opticsexpress.org/abstract.cfm?URI=oe-27-21-30055 %R 10.1364/OE.27.030055