02729nas a2200961 4500008004100000245008500041210006900126490000600195653000700201653000700208100002300215700001700238700001700255700002500272700002000297700001800317700002200335700002500357700002300382700001900405700002300424700002200447700002500469700001600494700002300510700002200533700002400555700002900579700002300608700003200631700003000663700001700693700001300710700001900723700003000742700002500772700002200797700001100819700002100830700002400851700001200875700001500887700002200902700002600924700002100950700003000971700002201001700001701023700002101040700002501061700002601086700002701112700002301139700002001162700002501182700002101207700002701228700001801255700002001273700001601293700002301309700001801332700001901350700002301369700002601392700002201418700001401440700001401454700002001468700002001488700002101508700002701529700001901556700002101575700002201596700001401618700002001632700001701652700001701669700001701686700001801703856004601721 2022 eng d00aNeurophotonic tools for microscopic measurements and manipulation: status report0 aNeurophotonic tools for microscopic measurements and manipulatio0 v910aKF10aMF1 aAbdelfattah, Ahmed1 aAhuja, Sapna1 aAkkin, Taner1 aAllu, Srinivasa, Rao1 aBoas, David, A.1 aBrake, Joshua1 aBuckley, Erin, M.1 aCampbell, Robert, E.1 aChen, Anderson, I.1 aCheng, Xiaojun1 aČižmár, Tomáš1 aCostantini, Irene1 aDe Vittorio, Massimo1 aDevor, Anna1 aDoran, Patrick, R.1 aKhatib, Mirna, El1 aEmiliani, Valentina1 aFomin-Thunemann, Natalie1 aFainman, Yeshaiahu1 aAlfonso, Tomás, Fernández1 aFerri, Christopher, G. L.1 aGilad, Ariel1 aHan, Xue1 aHarris, Andrew1 aHillman, Elizabeth, M. C.1 aHochgeschwender, Ute1 aHolt, Matthew, G.1 aJi, Na1 aKiliç, Kivilcim1 aLake, Evelyn, M. R.1 aLi, Lei1 aLi, Tianqi1 aMächler, Philipp1 aMesquita, Rickson, C.1 aMiller, Evan, W.1 aNadella, K.M., Naga Srini1 aNägerl, Valentin1 aNasu, Yusuke1 aNimmerjahn, Axel1 aOndráčková, Petra1 aPavone, Francesco, S.1 aCampos, Citlali, Perez1 aPeterka, Darcy, S.1 aPisano, Filippo1 aPisanello, Ferruccio1 aPuppo, Francesca1 aSabatini, Bernardo, L.1 aSadegh, Sanaz1 aSakadžic, Sava1 aShoham, Shy1 aShroff, Sanaya, N.1 aSilver, Angus1 aSims, Ruth, R.1 aSmith, Spencer, L.1 aSrinivasan, Vivek, J.1 aThunemann, Martin1 aTian, Lei1 aTian, Lin1 aTroxler, Thomas1 aValera, Antoine1 aVaziri, Alipasha1 aVinogradov, Sergei, A.1 aVitale, Flavia1 aWang, Lihong, V.1 aUhlířová, Hana1 aXu, Chris1 aYang, Changhuei1 aYang, Mu-Han1 aYellen, Gary1 aYizhar, Ofer1 aZhao, Yongxin uhttps://doi.org/10.1117/1.NPh.9.S1.01300102024nas a2200217 4500008004100000245008100041210006900122300001800191490000700209520135300216653000701569653000701576100002601583700002201609700002401631700002501655700001601680700001901696700002301715856006801738 2021 eng d00aSide-view holographic endomicroscopy via a custom-terminated multimode fibre0 aSideview holographic endomicroscopy via a customterminated multi a23083–230950 v293 a
Microendoscopes based on optical fibres have recently come to the fore as promising candidates allowing in-vivo observations of otherwise inaccessible biological structures in animal models. Despite being still in its infancy, imaging can now be performed at the tip of a single multimode fibre, by relying on powerful holographic methods for light control. Fibre based endoscopy is commonly performed en face, resulting in possible damage of the specimen owing to the direct contact between the distal end of the probe and target. On this ground, we designed an all-fibre probe with an engineered termination that reduces compression and damage to the tissue under investigation upon probe insertion. The geometry of the termination brings the field of view to a plane parallel to the fibre&\#x2019;s longitudinal direction, conveying the probe with off-axis imaging capabilities. We show that its focusing ability also benefits from a higher numerical aperture, resulting in imaging with increased spatial resolution. The effect of probe insertion was investigated inside a tissue phantom comprising fluorescent particles suspended in agarose gel, and a comparison was established between the novel side-view probe and the standard en face fibre probe. This new concept paves the way to significantly less invasive deep-tissue imaging.
10aKF10aMF1 aSilveira, Beatriz, M.1 aPikálek, Tomáš1 aStibůrek, Miroslav1 aOndráčková, Petra1 aJákl, Petr1 aLeite, Ivo, T.1 aČižmár, Tomáš uhttp://www.osapublishing.org/oe/abstract.cfm?URI=oe-29-15-23083